Identification of a novel Wnt5a–CK1e–Dvl2–Plk1- mediated primary cilia disassembly pathway
نویسندگان
چکیده
Kyung Ho Lee, Yoshikazu Johmura, Li-Rong Yu, Jung-Eun Park, Yuan Gao, Jeong K Bang, Ming Zhou, Timothy D Veenstra, Bo Yeon Kim and Kyung S Lee* Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA, Division of Systems Biology, Center for Proteomics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA, Division of Magnetic Resonance, Korea Basic Science Institute, Chung-Buk, Republic of Korea, Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA and Chemical Biology Research Center and World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Chung-Buk, Republic of Korea
منابع مشابه
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.
Non-motile primary cilium is an antenna-like structure whose defect is associated with a wide range of pathologies, including developmental disorders and cancer. Although mechanisms regulating cilia assembly have been extensively studied, how cilia disassembly is regulated remains poorly understood. Here, we report unexpected roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (Plk1...
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The primary cilium is a non-motile microtubule-based organelle that protrudes from the surface of most human cells and works as a cellular antenna to accept extracellular signals. Primary cilia assemble from the basal body during the resting stage (G0 phase) and simultaneously disassemble with cell cycle re-entry. Defective control of assembly or disassembly causes diverse human diseases includ...
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Polo-like kinase (Plk1) plays a central role in regulating the cell cycle. Plk1-mediated phosphorylation is essential for centrosome maturation, and for numerous mitotic events. Although Plk1 localizes to multiple subcellular sites, a major site of action is the centrosomes, which supports mitotic functions in control of bipolar spindle formation. In G0 or G1 untransformed cells, the centriolar...
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Primary cilia, which emanate from the cell surface, exhibit assembly and disassembly dynamics along the progression of the cell cycle. However, the mechanism that links ciliary dynamics and cell cycle regulation remains elusive. In the present study, we report that Polo-like kinase 1 (Plk1), one of the key cell cycle regulators, which regulate centrosome maturation, bipolar spindle assembly and...
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BACKGROUND The Dishevelled (Dvl) and Dishevelled-associated activator of morphogenesis 1 (Daam1) pathway triggered by Wnt5a regulates cellular polarity during development and tissue homoeostasis. However, Wnt5a signaling in breast cancer progression remains poorly defined. METHODOLOGY/PRINCIPAL FINDINGS We showed here that Wnt5a activated Dvl2, Daam1 and RhoA, and promoted migration of breast...
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